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KMID : 0624620220550040187
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BMB Reports
2022 Volume.55 No. 4 p.187 ~ p.191
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Exercise-induced beige adipogenesis of iWAT in Cidea reporter mice
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Kim Jin-Kyung
Go Hye-Sun
Kim Sol-Pin
Kim Il-Yong
Lee Yun-Hee
Oh Seung-Hyun
Lee Ho
Seong Je-Kyung
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Abstract
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Obesity is caused by an imbalance between energy intake and energy expenditure. Exercise is attracting attention as one of the ways to treat obesity. Exercise induces ‘beige adipogenesis’ in white adipose tissue, increasing total energy expenditure via energy dissipation in the form of heat. Also, beige adipogenesis can be induced by treatment with a beta-adrenergic receptor agonist. We developed a Cidea-dual reporter mouse (Cidea-P2A-Luc2- T2A-tdTomato, Luciferase/tdTomato) model to trace and measure beige adipogenesis in vivo. As a result, both exercise and injection of beta-adrenergic receptor agonist induced beige adipogenesis and was detected through fluorescence and luminescence. We confirmed that exercise and beta-adrenergic receptor agonist induce beige adipogenesis in Cidea-dual reporter mouse, which will be widely used for detecting beige adipogenesis in vivo.
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KEYWORD
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Beige adipogenesis, Cidea reporter mice, Exercise, Exerciseinduced browning, Genetically-engineered mouse
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